(18-07-2014, 05:04 PM)EvaMarie Wrote: Yes BUT progesterone also downregulates E receptors at least in women or bio males with a female hormonal balance But Im talking about bio identical oral P caps that would be much stronger than PC cream...

How that pertains to NBE and bio males though I donno

I do know despite having normal but no doubt lowered T levels and normal levels of E at least on a blood test I also had a good start with breast growth and feminization on NBE

Hi Eva,

Actually its reported to up-regulates E receptors. There's 3 kinds of PR, however PRA and PRB are most relevant over PRC. I'm familiar with the caps being reported stronger, and I'm also happy for ya!.

E upregulates expression of PR in the MCF-7 breast cancer cell line.21
Progesterone Receptor Isoform Functions in Normal Breast Development and Breast Cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829978/#!po=6.86275

Expression of progesterone receptor isoforms A and B is differentially regulated by estrogen in different breast cancer cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/11948015