Thanks Pom,
It's some pretty crazy stuff huh?, lol.
There's definetly a lot going on inside the male testes, 3-beta diol and 17b HSD (Hydroxysteroid Dehydrogenases) are a huge potential. I find these facts to be very promising.
a) It has been shown that 3β-diol may have hormonal activity, not acting through the AR, but rather as a ligand for both ERα and ERβ.
b) 3β-diol has higher affinity for ERβ [31], which is abundant in the efferent ductule epithelium [40].
c) In human testis, the 3β-diol concentration is higher than DHT and estradiol [44,45]. It is reasonable to postulate that high concentrations of this metabolite may enter the lumen of efferent ductules.
d) The existence of this estrogenic DHT metabolite has raised the possibility that estradiol may not be the major estrogen in males [29]. For instance, in the prostate there is a growing body of evidence that 3β-diol, acting through ERβ, may regulate important physiological events [26,28,32,46].
Also noteworthy is the fact that 3β-diol stimulates ERβ induced transcriptional activity equal to the cognate ligand estradiol, and the transcriptional selectivity of 3β-diol for ERβ is much greater than its binding selectivity [30,46]
It's some pretty crazy stuff huh?, lol.
There's definetly a lot going on inside the male testes, 3-beta diol and 17b HSD (Hydroxysteroid Dehydrogenases) are a huge potential. I find these facts to be very promising.
a) It has been shown that 3β-diol may have hormonal activity, not acting through the AR, but rather as a ligand for both ERα and ERβ.
b) 3β-diol has higher affinity for ERβ [31], which is abundant in the efferent ductule epithelium [40].
c) In human testis, the 3β-diol concentration is higher than DHT and estradiol [44,45]. It is reasonable to postulate that high concentrations of this metabolite may enter the lumen of efferent ductules.
d) The existence of this estrogenic DHT metabolite has raised the possibility that estradiol may not be the major estrogen in males [29]. For instance, in the prostate there is a growing body of evidence that 3β-diol, acting through ERβ, may regulate important physiological events [26,28,32,46].
Also noteworthy is the fact that 3β-diol stimulates ERβ induced transcriptional activity equal to the cognate ligand estradiol, and the transcriptional selectivity of 3β-diol for ERβ is much greater than its binding selectivity [30,46]
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