Its relevant to some degree. It's not important. DHT does more against NBE, than it could potentially do for NBE. There are other hormones that can upregulate receptors. Of course, there may be small amounts of DHT in the body, better off leaving that alone, or lowering it. Many times an antagonist also upregulates that receptor, but we don't know if this is always the case. That's why there's red reishi to lower DHT. It's way better to use progestogens, estrogens, and prolactin which all cause growth, to be agonists to their own receptors, while potentially upregulating the other two.

"Lowering DHT up-regulates the effects of estrogen in the body, and once DHT is converted to aromatase it can't be converted back to E" DHT is converted by aromatase?

This is interesting about progesterone regulation of ER, http://www.ncbi.nlm.nih.gov/pubmed/7629427 .

There was a database somewhere, where it showed which hormones interacted in what way with which receptors. If only that database was better made. It has a meter that goes by how many NIH studies showed an effect, rather than potency (which would be difficult if not impossible).