[Lotus]

Sorry byrony,

I gotta disagree with you here about withholding sexuality from your future spouse/loved one. Brain aromatase, which occurs throughout a male's lifetime can explain why some have no idea of future sexuality. So I don't buy we should've been upfront with our future mate. "Unless......such behavior/desires are truly known adhead of time, sure, then assign the blame/shame as it's been referred too. Adrenal deficiencies in both sexes explain a lot, so who's to say when GID surfaces, aromatase starts in fetal brain devoplment and w/secondary sexual determination. Hey lol, someone had to bring up science in right?, nothing personal

Action 1: deliberately withholding your sexuality from someone you desire in order to get them to fall in love with you marry you.

GYNECOMASTIA - AN OCCASIONAL MARKER?
metabolic and genetic conditions produce gynecomastia and mixed sex/gender individuals, potential links between aromatase, or other enzymes, causing both gynecomastia, and transgenderism, could exits.
The Journal Of Gender Speculation
http://www.oocities.org/gmapop04/


Aromatase and gynecomastia
http://www.researchgate.net/profile/Glenn_Braunstein2/publication/12585336_Aromatase_and_gynecomastia/links/0c96051af347814625000000.pdf?ev=pub_ext_doc_dl&origin=publication_detail&inViewer=true


Regulation of sex-specific formation of oestrogen in brain development: Endogenous inhibitors of aromatase
Abstract
Brain sexual differentiation occurs during steroid-sensitive phases in early development, and is affected particularly by exposure to oestrogens formed in the brain by aromatisation of androgen. The organisational effects of oestrogen result in male-specific neuronal morphology, control of reproductive behaviour, and patterns of gonadotrophin secretion. A question which still has to be resolved is what determines changes in aromatase activity effective for the differentiation of sexually dimorphic brain development during sensitive periods of growth. In the mouse, a sex difference exists at early stages of embryonic development in aromatase-containing neurones of the hypothalamus. The embryonic aromatase system is regulated later in foetal development by androgens. Testosterone treatment increases the numbers of aromatase-immunoreactive hypothalamic neuronal cell bodies. Kinetic evidence from studies on the avian brain suggest that endogenous steroid inhibitors of aromatase, probably formed within neuroglia, also have a role in the control of oestrogen production. Inhibitory kinetic constant determination of endogenous androgenic metabolites formed in the brain showed that preoptic aromatase is potently inhibited by 5α-androstanedione (Ki = 6 nM) and less strongly by 5β-dihydrotestosterone (Ki= 350 nM). Regulation by steroidal and possibly non-steroidal inhibitors may contribute to the special characteristics and plasticity in aromatase activity which develops at certain stages in ontogeny.
http://www.sciencedirect.com/science/article/pii/0960076095002375


Aromatase: Neuromodulator in the control of behavior ☆

Abstract
Estrogens are required for both the organization of the brain in early development and adult behavior. Two approaches have been used in our laboratory to study the behavioral role of brain aromatase. First, brain metabolism of testosterone (T) has been related to behavior in the same individual using a well established neuroendocrine model, the ring dove, in which estradiol-17β (E2) has specific effects on brain mechanisms of male behavior. Aromatase in preoptic area (POA) (a) has a high activity (Vmax) and strong substrate binding affinity (Km < 5 nM), (b) is regulated by both androgens and estrogens, and the type of regulation differs according to brain area, © is influenced by products of an endogenous inactivating pathway, 5β-reduction; 5β-dihydrotestosterone and other 5β-reduced metabolites appear to be non-genomic regulators of the brain aromatase. Preoptic aromatase activity is also influenced by photoperiod and socio-sexual stimuli. The codistribution of regulated aromatase activity and estrogen receptor cells is found to be T-dependent. Our second approach has been to relate the aromatase system to developmental sex differences in brain structure and behavior of the Mongolian gerbil. Neonatal gerbil aromatase is relatively active in the POA, but has a weaker T substrate-binding affinity (Km = 30 nM) than the dove. T acting via its metabolite, E2, masculinizes the sexually dimorphic area of the hypothalamus; the differentiating effect is asymmetric. We suggest that the regulation of the brain aromatase system may be lateralized during steroid-sensitive periods of development.
http://www.sciencedirect.com/science/article/pii/096007609390255U