[Epicene]

I haven't experienced any changes other than feeling very slightly calmer when on PM, but I haven't felt much else. I feel that a lot of the effects mentioned on the forum may very well be placebo effects (in regard to NBE) though.

That's a real posiblility. I also think that it really varies by each person as well, I can only attest to my personal thoughts going back over the last 5 yrs or so.

I'm sure the effects have to vary a lot. Reading about medicine, it seems like the only major mental effects estrogen is supposed to have are in emotions, pleasure, libido, and aggression. There may be more that just aren't generally accepted yet or I haven't read enough about, but I can definitely see those effects. When people say that they were driven to transition, their preferences changed, or experienced some other major change on outlook, I think that it must spur from their sense of feminization instead of NBE's direct effects.

I'm nowhere near the medical professional qualified to say anything about this though. It's just my opinion.