MSM at 2000mg per day,

Looking at : "nitrogen heterocycles can have effects that extend beyond the normally expected CYP inhibition"

nitrogen heterocyles
https://en.m.wikipedia.org/wiki/Heterocyclic_compound

Meaning that nitrogen heterocycles look real promising, for instance, indole is an anti-inflammatory, could be beneficial for chronic depression: as seen in the mini review

Indole as a Core Anti-Inflammatory Agent- A Mini Review
http://chesci.com/articles/csrl/v2i5/CS092043091.pdf