I think it now makes sense to add to the testosterone pathway metabolism......sheesh!, what am I thinking, wtf!, this ain't going to be easy identifying two steroid classes of metabolism. taking it a step further?, would be adding C19 aromatase lignans. What??? madness!!!



CYP17A1-lignans-CLA (conjugated linoleic acid) stimulates testosterone biosynthesis via leydig cells.

(odd because CYP17 inhibits testosterone).

CYP17A1-gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
http://www.ncbi.nlm.nih.gov/gene?cmd=search&term=1586