The bottom line,

this expression of CYP17 and CYP2B9 (maybe CYP2B10 too?) in dexymiroestrol can explain why some progress to the point of transition, it did for me in some respects. I think it ties into when we over express growth hormones it puts us over the top so to speak.

We can liken this to a flood, or cascade if you will of hormones we (males) haven't yet adapted to. In females this enzyme in PM has some effect, but not like what it does in males.

I doubt this hypothesis will get us males a "kitchen pass" (an excuse) for behaviors lol, but........ It's a start.