(28-01-2016, 07:16 PM)missboobshirt Wrote: So much happens on your thread when I go away for just a bit lol the excitment!

OO lotus is that your full areola? we have matching areolas lol! -does anime boobie squish- was that weird? LOL cept you seem to have more under boobie than me, I have to make a bank account so I can order NB, I am dying for more underboob

Lol, I think it moves like a snail. yeah that's the fullest the areola gets, most times its less than pictured. I do find using the large cup (over the XL's) can pull more under boob out. Just position the top of the dome above the nipple.

Imo I see the future of NBE changing in a direction that can identify which enzymes/proteins target specific hormone responses, in specially (herbs/meds) we use on a daily basis gets categorized by the signal or target tissue it expresses.


For instance, CYP2B9 feminizes in the liver and brain. It makes sense to list the corresponding supplements for the net effect (the pathway). I know lol, sounds like genome mapping right?. Only this version is NBE style.

In this case-something like this

Feminizing actions of enzymes
1) CYP2B9

a) herbs used-pueraria mirifica (PM)

Anti-Androgens

1) CYP17's (inhibits T)

a) herbs used -green tea, lemons, etc.



* Developmental action of estrogen receptor-α feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver


Pharmacogenetics, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Molecular Pharmacology (Impact Factor: 4.13). 10/1999; 56(3):473-7.
Source: PubMed
ABSTRACT
We have studied the roles of estrogen receptor-alpha (ERalpha) and the Stat5b form of STAT (signal transducers and activators of transcription) in sex-specific expression of Cyp2a4 (steroid 15alpha-hydroxylase) and Cyp2d9 (steroid 16alpha-hydroxylase) genes using ERalpha-deficient mice. ERalpha deficiency resulted in the repression of the female-specific Cyp2a4 and expression of the male-specific Cyp2d9 genes, respectively in females. In ERalpha-deficient males, the Cyp2d9 gene continued to be expressed. Nuclear localization of Stat5b occurs in both sexes of ERalpha-deficient mice, although it is normally observed in only wild-type males. Nuclear localization of Stat5b correlates with the repression of Cyp2a4 and expression of Cyp2d9, respectively. Because Stat5b was not detectable in liver nuclear extracts prepared from hypophysectomized ERalpha-deficient females, the regulation by ERalpha appeared to be mediated through a pituitary hormone (i.e., growth hormone). Thus, ERalpha appears to play a key role in the mechanism that inhibits nuclear localization of Stat5b in female mice, leading to feminization of a ERalpha-GH-Stat5b pathway and Cyp expression. Defaulting to this ERalpha-dependent mechanism results in localization of Stat5b to nuclei, which masculinizes the expression of Cyp genes in male mice.