[Lotus]

Estradiol binds slighty stronger than PM imo, even then, E2 doesn't exclusively bind to ER-a (boob growth receptors). PM preferentially binds to ER-b, which down regulates ER-a and its proliferative effects (breast cancer). I suppose you could take PM with E2 to help protect against cancer, I think you'd being slowing growth though. Loading up on anti-inflammatories and anti-oxidatants would help protect against cancers.


Red clover is actually stronger at estrogen receptors alpha (ER-a) over PM & E2.

Btw,

Estrogen, 17-beta-estradiol binds to both the ER alpha and ER beta receptors but not to androgen, progestin, or thyroiditis receptors. Each receptor version may turn on and off different responses in different cells in different parts of the body. For instance, ER alpha, promotes tissue growth and is found in greater amounts in the uterus, pituitary gland, and epididymis (the male sperm storing structure). ER alpha stimulates certain breast cancer cells to grow in response to estrogen hormones. The other version, ER beta, inhibits growth (possibly suppressing cancer) and prevails in the ovary and prostate. It can act like a dimmer switch for ER alpha, turning down its growth-stimulating effect.


Binding produces two distinct signaling routines: either slower via gene expression (hours to days) or very rapidly via molecular exchanges, or cascades (seconds to minutes). In both cases, the cell responds to the signals by manipulating proteins or building new ones. The affected workhorse proteins carry out specialized functions, such as controlling cell processes, building cells and tissues, or carting messages elsewhere within the cell or around the body.

The information for miroestrol is here https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1328187

I misread it, and thought it caused mammary cell multiplication=growth. They believe it to activate ER-alpha, and to possibly increase mammary growth on normal cells, based on its results on a test-tube of bad cells. It could promote growth of mammary cells whether they are healthy tissue or not. So for now, its just a lead, to find this out.

A better herb would encourage healthy breast tissue and stop malignant tissue, such as fenugreek, asparagus or hops.

Rhubarb tops the list, crazy!!