• P. mirifica of different sub-species, different locations*, and different harvesting period (e.g. Pueraria candollei Graph. Ex. Benth vs. Pueraria candollie var. mirifica) have different fingerprints and peak heights. This suggests that the level of actives and ratio are different.
From this information, it is possible that P. mirifica from one supplier could be more effective or less effective than P. mirifica from another supplier by a factor of 10 fold. For this reason, a standardized extract of P. mirifica root is recommended rather than the crude.
In 2000, it was reported that miroestrol may actually be deoxymiroestrol, the former possibly being an artifact of the combination of miroestrol and isomiroestrol during isolation work.(Chansakaow, S., Ishikawa, T., Seki, H., Sekine, K., Okada, M. and Chaichantipyuth, C. Identification of deoxymiroestrol as the actual rejuvenating principle of “Kwao Keur”, Pueraria mirifica. The known miroestrol may be an artifact. J Natural Products, 2000; 63: 173-175.) Work is on-going to confirm this finding.
(Linked pdf).
From this information, it is possible that P. mirifica from one supplier could be more effective or less effective than P. mirifica from another supplier by a factor of 10 fold. For this reason, a standardized extract of P. mirifica root is recommended rather than the crude.
In 2000, it was reported that miroestrol may actually be deoxymiroestrol, the former possibly being an artifact of the combination of miroestrol and isomiroestrol during isolation work.(Chansakaow, S., Ishikawa, T., Seki, H., Sekine, K., Okada, M. and Chaichantipyuth, C. Identification of deoxymiroestrol as the actual rejuvenating principle of “Kwao Keur”, Pueraria mirifica. The known miroestrol may be an artifact. J Natural Products, 2000; 63: 173-175.) Work is on-going to confirm this finding.
(Linked pdf).
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