08-04-2016, 12:44 AM
(07-04-2016, 12:16 AM)Tanya Marie Squirrel Wrote: so perusing around like I usually do in the event of discovery, I came across this :
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943728/
"Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth"
it is in regards to the use of rosemary extract as a blocker to AR (androgen receptors), apparently its main purpose was to kill off or create aptopsis (cell death) in prostate cancer. interesting. Not sure what it would do to the testes and or other decidedly "male" parts that one wishes to make go away. I do know that rosemary hair rinse is good for the scalp and hair growth, though I do not know what it would do to other parts of the body. especially if its in an extract form.
Lotus, your thoughts?
It's interesting for sure, degrading prostate cancer cells via androgen receptors certainly looks promising. It also looks like it could disrupt ER-a (estrogen receptor alpha) though, like it states: a dual effect.
From the study:
"Previously, we have reported carnosol, an ortho diphenolic diterpene, to promote apoptosis in multiple prostate cancer cell lines while modulating 5' adenosine monophosphate-activated protein kinase (AMPK) pathway [20]. More recently, we have reported a unique attribute of carnosol to promote dual disruption of AR and ERα [15]. "


