(10-05-2016, 02:28 PM)jannet.duff Wrote: So if I read between the lines, pharma HRT effects ER-a, but PM effects ER-b. So, if I add some PM back into the mix it should assist growth rather than hinder it.

Yes E2 binds with ER-a, however!........bioidentical progesterone is still needed to complete ductal side branching (rounding). Too much prolactin produces tubular growth, while E2 produces elongation. Add in growth hormone and essential fatty acids and hopefully things start happening lol, (albeit a slow process).


I still wouldn't use PM with HrT:

Quote:miroestrol competes with estrogen and blocks the excessive stimulation of estrogen receptors often seen with breast or endometrial cancer.