[Lotus]

I look at this study and see a glaring fact, FSH is downregulated, LH is lowered too (but that's ok because how it reduces T signal from the hypothalamus). FSH (follicle stimulating hormone) is what concerns me, meaning we lose its ability to stimulate aromatase, (or its ability to synthesize it). So, in other words, one would still need to add pro-aromatase............I do have a prossible solution.

Another thing is how E2 does given every other night, now this is peaking my curiosity.

When micronized E2 was given in a dosage of 0.5 mg sublingually every other night, increased circulating levels of estrogens continued to be elevated at a minimum two and one-half fold baseline level for the week of study.

Serum concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly decreased within 6 hours. The rise in E2 was early and peaked in the first 2 hours. The rise in E1 was slower and progressive, reaching its maximum thirteenfold increase at 4 hours, and remained two and one half times the baseline of 29 pg/ml at 24 hours, whereas E2 returned to the baseline level of 24 pg/ml. When micronized E2 was given in a dosage of 0.5 mg sublingually every other night, increased circulating levels of estrogens continued to be elevated at a minimum two and one-half fold baseline level for the week of study.