[Lotus]

Glad to provide you with a proverbial bone to chew on Lotus!

Doc says there is very little research on SHBG and how it gets to be so high. She wasn't worried but curious. The Spiro will take care of it I think.

As to the E, I agree to being perplexed.t

A curve ball for sure. I ran the numbers again (4th time lol). I think I miscalculated. Your free E2 is .488% which lines up with the 17pg/mL you tested at. DHEA and DHT are within normal limits, so.......that takes the aromatase theory out, in freeing up mote SHBG for higher unbound E2 (from SHBG) it would need to be lowered by 150 nmol/L to 55 nmol/L, to hit 1.8% free E2........4-5% free E2 would be astronomical.......1.8% is puttering along, .448% not so much. But, that still leaves the perplexing question, how'd you get the lovely results?. Your dedication is my guess, plus the NBE program too.