[Lotus]

Lotus, isn't WP's prime usage to stop T production.

Not trying to answer for Lotus (I am not qualified to do that!), but I believe WP does not stop T production but rather promotes aromatization of T which converts it into E. Or something like that.

Your right my choice of words were wrong, is it correct to say it ties up your Free T, so leaves less for conversion to DHT. My thoughts are, do you want to cycle an AA ??. The PM I could see ( I cycled my own - 5 days off every 5 weeks )

Paeonia lactiflora decreases testosterone production by inhibiting the conversion of delta 4-androstenedione to testosterone. In the ovaries WP stimulates aromatase activity to promote estradiol synthesis. WP inhibits DHT in skin (via sebum production by the sebaceous glands).

PI3K/Akt/mTOR signaling is mediated by Paeoniflorin (WP). This is quite significant news btw, I'll have to explain in another thread.

Hi, Lotus,
Sorry to just ask bluntly instead of researching, but I already went the research route once and found it too much work. ;-)
Young lady has PCOS, and thus high T. Would White Peony then help her control the symptoms of PCOS better, especially WRT Testosterone over-production?
She likes being a girl, so facial hair and bad periods and an overly-aggressive attitude are undesired...

Thank you
-Dianna

Try to look at the whole solution, meaning what's is the cause of the PCOS. My approach would be at lowering inflammation, and we know that's where mutations occur in aterial cells, (clog arteries and adding inflammation). Acne is an example of inflammation, too much polyunsaturated fats. So.... to solve inflammation you change the ratio of fats in cells, via the blood. In other words, stop feeding inflammation and reduce our dependence of w6 fats. Personally, I think the w6 to w3 ratio should be 1:1 to 1:3.

Also, I'd have this young lady get some labs done to identify what androgens are out of whack. Btw, normal testosterone range in females is somewhere between 30 ng/dL to 90 ng/dL, males in comparison is 300 ng/dL to 1200 ng/dL. Keep in mind, 50% of E production in premenopausal women is found in adipose tissue, 70% in postmenopausal women.........that's somewhere where the males at BN fit (postmenopausal women).

WP inhibits T in the ovaries, though it stimulates E in the ovaries too, which E could benefit PCOS from high levels of T being produced. Now, spiro is used as a pharma approach, though other options exist.

Good luck Diana, i hope things work out for the better with this young lady.

apologies to OP (spanky) it looks like a high jack on my part.