24-11-2016, 04:51 AM
(24-11-2016, 12:31 AM)Sofia Lauren Bunny Wrote: If my free T is just okay, where should it be? Thank you Lotus for the information and analysis, here is the additional information you requested.
Progynova (Estradiol) 2 mg Morning, 2 mg Evening
Aldactone (Spironolactone) 50 mg Morning, 50 mg Evening
Fincar (Finasteride) 2.5 mg morning 2.5 mg evening
Additionally I take low dose asprin, probiotics, vitamin C, and Calcium.
Bunny, forgive me
allow me rephrase:
your T has decreased in the neighborhood of 80% since April 2016......that's dramatic (or significant). Free T is similar result, as far as I know??, there's no playbook on where free T should be. My concern is how much free T is an ideal fraction for feminizing. One theory is reducing DHT further upstream (e.g. androstenedione), a precursor where DHT prefers the SR5A enzyme (type I to be specific). This is based on recent discoveries known as horomine refractory prostate cancer (multiple human cells lines). targeting this alternative pathway involves the conversion of AD to 5α-dione. Meaning inhibiting DHT synthesis in the conversion of androstenedione to 5α-dione.
Quote:The enzyme 5α-reductase catalyzes the 5α-reduction of 4-dione whereas the 17β-hydroxysteroid dehydrogenase catalyzes the transformation of 4-dione to testosterone or 5α-dione to dihydrotestosterone (DHT).
Steroidal 5α-reductase inhibitors using 4-androstenedione as substrate.
https://www.ncbi.nlm.nih.gov/m/pubmed/21299452/
Your estrogen is also remarkable. By the looks of it, your HRT is pretty much standard dosages, which makes the results very interesting considering it's not overkill.
L.

