I have read that Silybin down-regulates and inhibits ERα in breast cancer cells in some studies, does this have any other meaning, e.g. how does Silybin affect ERα in general? Also I have read it has an anti-aromatase side as well. Is it like pumpkin seeds which while being potent anti-androgen (from what I have read) is also an anti-aromatase and ERα inhibitor? Is all this good or bad for NBE?