MSM-(new findings)
Growth hormone (GH) is regulator of bone growth and bone metabolism. GH activates several signaling pathways such as the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) pathway, thereby regulating expression of genes including insulin-like growth factor (IGF)-1. GH exerts effects both directly and via IGF-1, which signals by activating the IGF-1 receptor (IGF-1R).
https://www.ncbi.nlm.nih.gov/pubmed/23071812
Transcription of the genes encoding both ERα (Esr1) and ERβ (Esr2) is stimulated by PRL through the Jak2–Stat5 pathway and Stat5-response elements that are located in each of the Esr promoters.
http://www.cell.com/trends/endocrinology-metabolism/pdf/S1043-2760(03)00030-4.pdf
This means MSM stimulates the stat5 pathway and thereby in the process stimulates estrogen receptors, (ERα (Esr1) and ERβ (Esr2)....(awesome huh?).....finally, the connection is clear.
Growth hormone (GH) is regulator of bone growth and bone metabolism. GH activates several signaling pathways such as the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) pathway, thereby regulating expression of genes including insulin-like growth factor (IGF)-1. GH exerts effects both directly and via IGF-1, which signals by activating the IGF-1 receptor (IGF-1R).
https://www.ncbi.nlm.nih.gov/pubmed/23071812
Transcription of the genes encoding both ERα (Esr1) and ERβ (Esr2) is stimulated by PRL through the Jak2–Stat5 pathway and Stat5-response elements that are located in each of the Esr promoters.
http://www.cell.com/trends/endocrinology-metabolism/pdf/S1043-2760(03)00030-4.pdf
This means MSM stimulates the stat5 pathway and thereby in the process stimulates estrogen receptors, (ERα (Esr1) and ERβ (Esr2)....(awesome huh?).....finally, the connection is clear.
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