(25-05-2017, 11:41 PM)EndlessEden_mn2010 Wrote: Lotus: 

Iif im reading this correctly... the pathway is

Estrogen pathway

HSD3B1 >HSD17B1 >CYP27B1&CYP24 >CYP1A1(!!!!) >CYP1A2 >CYP17A1 >CYP1B1 >COMT(catechol-O-methyltransferase) >UGT1A1(uridine diphospho-glucuronosyltransferase) >SULT1A1&SULT1E1(sulfotransferases) >ESR1&ESR2

and Cimetidine Inhibits(how much btw, <100%?) CYP1A2, wouldnt that mean it is STOPPING growth?? 
Stopping the CYP1A2(estrogen link), would stop E2 from being processed? or am i misreading this?

NOTE: I am prescribed CIMETIDINE() - IF its going to inhibit Breast growth or feminisation, i need to stop it now...

Hi Eden, 

Quite the opposite....cimetidine is an H2 receptor inhibitor, meaning when histamine is inhibited in stomach acid (gastrin) estradiol (in plasma) will increase....and femininaztion is likely. When you inhibit let's say the enzyme "CYP3A4" you inhibit testosterone which then upregulates Estrogen. When CYP3A4's enzymes are induced (e.g. St.Johns wort) its inhibiting E and likely promoting T.

On the estrogen pathway...my apologies but it should've read estrogen pathway(s).