(20-09-2017, 04:57 AM)Aria Wrote: So, in short!!!   Since I'm taking MSM for my arthritis, Spiro for Androgen suppression and Estradiol for feminizing....  that's the reason for why my GD said I'm above the curve since i'm at a relative low dose rate of HRT!  Then, can I assume, that all the bad things that could happen under normal HRT is lessoned do to better response to HRT?

Yes, i believe this....but there's so much more. For example...E2 lowers IGF-1...but stimulates growth hormone. Losing IGF-1 piles on depression, but so does the loss of nitrogen in bodily waste. So, to curb depression replace lost nitrogen in our daily diet, but this also will stimulate IGF-1.... win-win eh?.