[Jennipher]

Inhibiting cytochrome CYP450 3A4 actually increases a higher bioavailability of certain drugs, thus...inducing the very same enzyme means it's not benefiting E. (St. John's wort is a good example inducing CYP-3A4). What we (aria and i) found out (3-4 years ago) is that statins inhibit T and benefits E.

Keep in mind, PM needs liver activation to synthesize dexoy & miroestriol, there's a high significance that an interconversion between E2(estradiol) & E1(estriol) are working under the hood..or...like a very active ping-pong game, needless to say PM acts more like estriol (less powerful) than E2, which as we know E2 is the highest feminizing hormone, but " free E2 " is technically the mother of all feminzing because it's bioactive to E receptors.

Thanks so much Lotus! I had hoped you’d jump in! That's good news for those of us on statins. Seems like a symbiotic relationship between PM and statins on lowering cholesterol and T and putting E to work! Win-Win!    

Question- with the impact of statins on T, are things like spearmint, Reishi and White Peony still needed in an NBE regimen, or is the statin (I’m on 40mg Lipitor daily) enough to lower T/inhibit conversion to DHT?