[PaulaJ]

As soon as you get out of bed. 
Not, after your first cup of coffee. 
As soon as you wake up. 

Whether it makes a big difference or not, I don’t fully know. 
But, Lotus demonstrated a while back that your level of 
Testosterone rises dramatically about 30 minutes after waking up.

I go with one before first cup of coffee, and one after breakfast...

Do not take with alcohol: (well that's happening most nights until the world doesn't suck), so I'll take it the small window I'm sober...