I have been on HRT off and on since 1999. The latest stint is 5 years. In 5 years I have gone from B cup like boobs (they measured differently to C or D. I quit smoking in August and now am a D cup. 

Mainly estradiol 1mg bid, 100mg spiro bid. 


Before and After on Imgur

Lesson: Tobacco and boobs do not get along!