(09-07-2020, 03:47 AM)Troublewithnibbles Wrote:So forskolin will inhibit PDE without the help of other PDE inhibitors?
It does, but there's another phosphodiesterase inhibitor I find interesting...aloe vera.
https://www.researchgate.net/publication/256539509_Chemical_constituents_of_Aloe_barbadensis_Miller_and_their_inhibitory_effects_on_phosphodiesterase-4D
Somatostatin inhibits oral estradiol, prolactin, growth hormone and stomach gastrin.
Somatostatin stimulates insulin, which has deleterious effects to breast growth. So, the new goal needs to inhibit somatostatin. Somatostatin also inhibits the cAMP/PKA/CREB pathway...which is the breast growth pathway.
More info to follow bringing all this into focus.
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