Hi PleasantlyFascinated,
I'll take MSM 2-3g and melatonin at bedtime for various reasons. I've tried Alpha GPC but it keeps me up. Fasting lowers the androgen index in males. I know you fast for 15hrs, from study's I've read IF and alternate day fasting achieve the same results...tbh, I've haven't tried AF so can't offer an opinion. Have you thought about stretching it to 16hrs?...20hrs of IF seems to be the sweet spot. I think a 48hr prolonged fast spike HGH somewhere around 1500%, beats the hell out taking MK-677 (I'll share a post made on the ladies forum giving a hypothesis on why people don't see results using MK-677).
I see your program hits a lot of aspects towards fitness & NBE goals. Saw palmetto might be redundant if using reishi. From previous research saw palmetto inhibits progesterone receptors and lowers estrogen which might work against desired results.
On inhibiting somatostatin, it's in breast growers' interest to inhibit its action. Meaning when somatostatin is released it inhibits prolactin, oral estradiol, adenylyl cyclase, growth hormone and TSH (thyroid releasing hormone)...which also inhibits TRH (Thyrotropin releasing hormone). And inhibiting TRH means no prolactin production. In other words prolactin stimulates the aveolargenesis in the lobules of breasts. Vitamin D3 and MSM are very important for alveolar stimulation.
When you inhibit adenylyl cyclase you inhibit ATP production, and the end result of that is inhibiting aromatase.
See, estrogen stimulates prolactin and growth hormone, so by somatostatin inhibiting their action it seems like an awful waste for breast growth.
https://www.sciencedirect.com/topics/neuroscience/somatostatin
Most effective way to block somatostatin is in the stomach. Supplements for inhibiting somatostatin are listed in post #4192. Still working on adding other inhibiting agents to the list asap.
When you inhibit adenylyl cyclase you inhibit ATP production, and the end result of that is it inhibits aromatase.
Somatostatin is used for treating Gigantism and Acromegaly, and other various conditions:
https://www.drugs.com/drug-class/somatostatin-and-somatostatin-analogs.html
Somatostatin agonists for treatment of acromegaly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697610/
I'll take MSM 2-3g and melatonin at bedtime for various reasons. I've tried Alpha GPC but it keeps me up. Fasting lowers the androgen index in males. I know you fast for 15hrs, from study's I've read IF and alternate day fasting achieve the same results...tbh, I've haven't tried AF so can't offer an opinion. Have you thought about stretching it to 16hrs?...20hrs of IF seems to be the sweet spot. I think a 48hr prolonged fast spike HGH somewhere around 1500%, beats the hell out taking MK-677 (I'll share a post made on the ladies forum giving a hypothesis on why people don't see results using MK-677).
I see your program hits a lot of aspects towards fitness & NBE goals. Saw palmetto might be redundant if using reishi. From previous research saw palmetto inhibits progesterone receptors and lowers estrogen which might work against desired results.
On inhibiting somatostatin, it's in breast growers' interest to inhibit its action. Meaning when somatostatin is released it inhibits prolactin, oral estradiol, adenylyl cyclase, growth hormone and TSH (thyroid releasing hormone)...which also inhibits TRH (Thyrotropin releasing hormone). And inhibiting TRH means no prolactin production. In other words prolactin stimulates the aveolargenesis in the lobules of breasts. Vitamin D3 and MSM are very important for alveolar stimulation.
When you inhibit adenylyl cyclase you inhibit ATP production, and the end result of that is inhibiting aromatase.
See, estrogen stimulates prolactin and growth hormone, so by somatostatin inhibiting their action it seems like an awful waste for breast growth.
https://www.sciencedirect.com/topics/neuroscience/somatostatin
Quote:Antibody experiments (1) have clearly shown that basal GH levels are elevated when somatostatin is neutralized.
Somatomedin C has also been implicated in the negative feedback regulation of GH, at least partially by stimulating release of somatostatin (5).
https://link.springer.com/chapter/10.1007/978-1-4615-7886-4_18
Most effective way to block somatostatin is in the stomach. Supplements for inhibiting somatostatin are listed in post #4192. Still working on adding other inhibiting agents to the list asap.
When you inhibit adenylyl cyclase you inhibit ATP production, and the end result of that is it inhibits aromatase.
Somatostatin is used for treating Gigantism and Acromegaly, and other various conditions:
https://www.drugs.com/drug-class/somatostatin-and-somatostatin-analogs.html
Somatostatin agonists for treatment of acromegaly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697610/
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