Hi Steffy Anne,
The strongest one-two punch for anti-androgens are the duo of Reishi w/Green Tea (i prefer matcha). In particular of green tea is actually EGCG (the benefits of EGCG has been detailed throughout this thread)
If I can explain how EGCG works it would go like this:
EGCG inhibits cancer (LNCaP cells), and the nuclear translocation and protein expression of androgens (DHT)
In other words. EGCG prevents androgens from going into the nucleus and mitochondria which then can go on to what's called protein expression. And that's a fancy way of saying how if this (# protein expression) happens Dht goes on to do its business of ruining breast growth, hair loss, masculinization, yada yada.
And then on top of that DHT increases R.O.S (reactive oxygen species) which f*ck up mitochondria by damaging (oxidative stress) the cells...thus we take antioxidants. This is where Green Tea comes in, hoorah because it's a super charged antioxidant.
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.10-167924
Steffy, I hope this answers your question. However, the next step beyond the herbal route is pharma anti-androgens. Spironolactone and Finasteride have side effects as we know. And they both lower progesterone (not good for breast growth and feminizing). My advice on that is to add GABA (which is stimulated by Theanine in green tea)...yay. Finasteride inhibits allopregnanolone, which through its pathway causes depression, but we just fixed that, right?. Or counter to that and add Dopamine via Mucuna pruriens
Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213977/
The strongest one-two punch for anti-androgens are the duo of Reishi w/Green Tea (i prefer matcha). In particular of green tea is actually EGCG (the benefits of EGCG has been detailed throughout this thread)
If I can explain how EGCG works it would go like this:
EGCG inhibits cancer (LNCaP cells), and the nuclear translocation and protein expression of androgens (DHT)
In other words. EGCG prevents androgens from going into the nucleus and mitochondria which then can go on to what's called protein expression. And that's a fancy way of saying how if this (# protein expression) happens Dht goes on to do its business of ruining breast growth, hair loss, masculinization, yada yada.
And then on top of that DHT increases R.O.S (reactive oxygen species) which f*ck up mitochondria by damaging (oxidative stress) the cells...thus we take antioxidants. This is where Green Tea comes in, hoorah because it's a super charged antioxidant.
- And as I (and you) know, Resihi inhibits DHT by 80%-90% (I've attached numerous studies).
- From my calculations (from science papers) of converting to body weight (say around 200 pounds) 220 mg is enough to inhibit DHT using Green Tea.
- EGCG is similar to Bicalutamide (brand name casodex), per the study.
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.10-167924
Steffy, I hope this answers your question. However, the next step beyond the herbal route is pharma anti-androgens. Spironolactone and Finasteride have side effects as we know. And they both lower progesterone (not good for breast growth and feminizing). My advice on that is to add GABA (which is stimulated by Theanine in green tea)...yay. Finasteride inhibits allopregnanolone, which through its pathway causes depression, but we just fixed that, right?. Or counter to that and add Dopamine via Mucuna pruriens
Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213977/
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