[Dibraru]

Hi Nipply, 

I'm going to make one final post on progesterone, micronized progesterone (is bioidentical to human progesterone) progestin is synthetically made..not identical to human progesterone. 

This is not just a Lotus thing, it's stated in multiple scientific literature papers. For every 6 science papers on micronized progesterone you'll find 6 more stating the usage of synthetic progestin. IMHO it's misinformation about the safety of progestin. Personally?, I wouldn't put that shit in my body. Additionally, BC (birth control products) are made with synthetic progestin...I feel sorry for girls who are put on it, I doubt they get the proper information to MAKE an informed decision. 

As you can see from the attached science paper the risks significantly increase using synthetic progestin with oral estradiol. 

Nipply, the Progesto-Life brand is USP micronized progesterone, its bioidentical to human progesterone, that's why it works. I've used it for 8 yrs. and if it didn't work I wouldn't use it. And no, I'm not a spokesperson or paid in any way shape or form. And I wouldn't advise using oral progestin with micronized progesterone, that makes no sense.

Additionally, you'll see the little caveat that synthetic progestin increases androgens. Most HRT (if not all) medical professionals that treat HRT patients won't use progestin, they subscribe micronized progesterone. 

So, judge for yourself people, it's your body. 

Effectiveness of transdermal oestradiol and natural micronised progesterone for menopausal symptoms

TYPE OF PROGESTOGEN

The progestogens used in HRT have distinctive biological and clinical profiles. They can be either a synthetic progesterone, which differs in structure from naturally occurring progesterone, or natural micronised progesterone (MP). This was developed in the 1980s and is produced from the yam plant. MP is chemically and structurally identical to human progesterone, and it is therefore often referred to as ‘body identical’ or ‘natural’. The process of micronisation allows for a steady and even absorption. This can be prescribed either continuously or cyclically. The only current preparation available in the UK is Utrogestan® (Besins Healthcare (UK) Ltd).
Risk of venous thromboembolism

The risk of VTE is greater in women using medroxyprogesterone acetate compared with other progestogens. The risk of VTE increases by about 50% in women using oestrogen plus synthetic progestogens, compared with oral oestrogen alone. There does not appear to be this increased risk in women taking natural MP.

Cardiovascular risk

MP has been associated with a lower cardiovascular risk and has a neutral effect on blood pressure compared with synthetic progestogens, which have androgenic activities.

Read further here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146001/

Then there is one more question from me to the progesterone. Would using the cream cause issues with the functionality of my sex organ?

And is it recommended to use progesterone from the beginning or only later on?