I've been meaning to post research regarding how taking micronized progesterone (hrt pill form) split into two forms. Meaning 100mg orally & 100mg rectally at bedtime, which is usually the standard dose most people take. Why take it this way? you benefit orally when processed through the liver and its catabolic effects on protein metabolism via promoting ketogenesis and rectally to favor storage of depot fat in adipose and breast tissue. Some users (including myself) have been trying this method for a couple of months, personally I like the results so far. There's much debate over on reddit (Dr. Powers sub reddit) regarding progesterone and the 3α-Androstanediol gene variant backdoor pathway leaking to DHT. My recent labs DO NOT indicate I have this variant…even using this split form of progesterone, I had the 3α-Androstanediol tested and it came in under the threshold.
Metabolic effects of progesterone.
Kalkhoff RK. Am J Obstet Gynecol. 1982.
https://pubmed.ncbi.nlm.nih.gov/7039319/
Metabolic effects of progesterone.
Kalkhoff RK. Am J Obstet Gynecol. 1982.
https://pubmed.ncbi.nlm.nih.gov/7039319/
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