(13-09-2022, 11:14 AM)HelloDiDi Wrote: It seems so. My suspicion is that your estrogen levels aren't enough to fully suppress T on their own or otherwise stopping cypro would have had no effect. Cypro indeed has a long half life and the build up and crash both will take time. I think for me it was very apparent around three weeks or so, in line with information I read about it.
I suspect that the progestin like effect it has is very mild on small doses and it doesn't interfere much with bio identical progesterone. Same with how it raises prolactin, its rare to have a problem with that while being on small doses but this seems to be highly individual. 12.5mg and lower should be enough for complete T suppression with tiny chance for any side effects. Of course there are better blockers, but it seems they're all very expensive. I'm on cypro for efficiency and price. I would rather avoid it too if I could but for now its the only viable option.
I used Red Reishi for DHT suppression and it seemed to be very efficient on it. Its also healthy stuff, helps to boost immune system and so on. I have been thinking of taking it on the side just for its health benefits. It curbs DHT but doesn't touch free T.
Glandular therapy really helps with weight gain. Something to keep in mind if planning to try it, just watch you wont over eat, cut down carbs and maybe add some exercise and it should be all fine if you decide to go on with it. From what I've noticed, it seems that pituitary supplement does more about weight gain than bovine ovaries do, but both give a little kick into it. Since spring, I've been able to lose some weight despite being on glandulars which is really nice. Its been slower than I anticipated but it can obviously be done. Weight cycling is something to look into, it seems to be helpful with fat distribution.
I feel even worse today, so it's safe to say estrogen alone isn't enough. Deciding to start Cypro again tonight and use the blood test as a way of seeing how well a small amount of Cypro suppresses. I'll be trying 6.25mg every other day to get that suppression back and figure it out from there. I already have progesterone cream, and I'd prefer that to be my source of progesterone rather than this. I mean a bit of prolactin could help, but, I'd rather find it from a risky source.
There's an interesting table here that states for natal-female like progestenic effects from Cypro, the optimal dose is 3.125mg per day. No source, but interesting nonetheless.
Either way, for the future, I'd like to find a way to maybe work Bica in. I know it's effective since I've used it, and I'm wondering if I could get away with a way lower dose due to most of my testosterone being taken out by estrogen.
Bicamutalide. 25-100mg/day. 10-25mg/day will block female T levels which is achieved via estadiol at a sufficent dose. If not taking estradiol or if you have male levels you will need 50mg/day or more. 100-150mg/day at minimum appears to be need to fully or near-fully block 600ng/dL T.
Bica is expensive, but if we can get away with using way less of it, that might be far more financially viable. By my math, if you find 50 50mg pills of Cypro at 50$ and dose at 6.25mg every other day, it'd be 0.09 cents per dose. Presuming you can find Bica for 50$ for 50 50mg pills and took 12.5mg every day, there are some places out there to find it at that price, that'd be 0.25$ per dose... that's a lot of 50s. Something to look into in the future.
Regarding the weight gain, yeah. I was eating around 3000 calories a day and gaining nothing. The second I started the glandular therapy, I put on 5 pounds in a couple of weeks. Knocked 1000 calories off my diet and balanced out. It's nice to have a sort of toggle for if you're losing or gaining weight. The goal definitely is to weight cycle at some point by stopping the glandular therapy.
Anyways, future plans, suppress T, start increasing progesterone. I'm still stuck in Tanner Phase 3. Maybe getting back on cypro will help a little bit, but mainly gonna try to keep doing the cream daily and see what my blood test reads.

