Hi Mel, Stevenator, Lady Charlotte,
Two studies (same research) had different results on carb metabolism using oral capsules. Interesting that the lower dose study using 1,000mg lyophilized RJ significantly decreased fasting blood glucose (FBG) in diabetic individuals compared to a placebo group compared the other study using 3,000mg RJ
Effectiveness of royal jelly supplementation in glycemic regulation: A systematic review
In addition to in vitro studies, RJ administration has demonstrated therapeutic potential in human and rodent diabetic models. In a randomized controlled trial, Khoshpey et al[12] found that daily ingestion of capsules containing 3000 mg RJ for eight weeks significantly decreased fasting blood glucose (FBG) in diabetic individuals compared to a placebo group. However, the effects of RJ administration on glycemic control outcomes are inconsistent across studies, possibly due to considerable variation in studied population and intervention. For example, while Khoshpey et al[12] found no significant change in carbohydrate (CHO) intake in the RJ-treated group, Pourmoradian et al[13] found a significant decrease in CHO intake in diabetic individuals in response to daily ingestion of 1000 mg lyophilized RJ for eight weeks. Rodent studies have shown a more pronounced effect: Ghanbari et al[14] found that addition of 100 mg/kg RJ in drinking solution improved circulating insulin and FBG in diabetic mice to levels similar to the healthy control group. Zamami et al[15] observed a similar magnitude of effect in insulin-resistant rats following administration of 300 mg/kg enzymatically treated RJ.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379731/
10H2DA has demonstrated interactions with estrogen receptors leading to alterations in gene expression, potentially including those involved in glucose regulation[11].
BTW, 10-hydroxy-2-decenoic acid…stands for (10H2DA), a fatty acid unique to RJ:
An in vivo study examining life-extending effects of RJ found that 10H2DA induces upregulation of molecules involved in caloric restriction, reducing energy intake[10]. 10H2DA has demonstrated interactions with estrogen receptors leading to alterations in gene expression, potentially including those involved in glucose regulation[11]. The glucose modulating role of 10H2DA is the most well-investigated mechanism by which RJ might benefit patients with T2D, although other RJ components, such as sebacic acid, may also be important.
Two studies (same research) had different results on carb metabolism using oral capsules. Interesting that the lower dose study using 1,000mg lyophilized RJ significantly decreased fasting blood glucose (FBG) in diabetic individuals compared to a placebo group compared the other study using 3,000mg RJ
Effectiveness of royal jelly supplementation in glycemic regulation: A systematic review
In addition to in vitro studies, RJ administration has demonstrated therapeutic potential in human and rodent diabetic models. In a randomized controlled trial, Khoshpey et al[12] found that daily ingestion of capsules containing 3000 mg RJ for eight weeks significantly decreased fasting blood glucose (FBG) in diabetic individuals compared to a placebo group. However, the effects of RJ administration on glycemic control outcomes are inconsistent across studies, possibly due to considerable variation in studied population and intervention. For example, while Khoshpey et al[12] found no significant change in carbohydrate (CHO) intake in the RJ-treated group, Pourmoradian et al[13] found a significant decrease in CHO intake in diabetic individuals in response to daily ingestion of 1000 mg lyophilized RJ for eight weeks. Rodent studies have shown a more pronounced effect: Ghanbari et al[14] found that addition of 100 mg/kg RJ in drinking solution improved circulating insulin and FBG in diabetic mice to levels similar to the healthy control group. Zamami et al[15] observed a similar magnitude of effect in insulin-resistant rats following administration of 300 mg/kg enzymatically treated RJ.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379731/
10H2DA has demonstrated interactions with estrogen receptors leading to alterations in gene expression, potentially including those involved in glucose regulation[11].
BTW, 10-hydroxy-2-decenoic acid…stands for (10H2DA), a fatty acid unique to RJ:
An in vivo study examining life-extending effects of RJ found that 10H2DA induces upregulation of molecules involved in caloric restriction, reducing energy intake[10]. 10H2DA has demonstrated interactions with estrogen receptors leading to alterations in gene expression, potentially including those involved in glucose regulation[11]. The glucose modulating role of 10H2DA is the most well-investigated mechanism by which RJ might benefit patients with T2D, although other RJ components, such as sebacic acid, may also be important.
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