While researching I came across something interesting on diosgenin which as you may know is in Fenugreek, Wild Yam and Shatavari and a few other herbs.
The present study shows that diosgenin exerts the antidepressant activity, which is associated with the enhancement of neurotrophic function and the inhibition of inflammatory and neuroendocrine activities via the regulation of gut microbiota.
In addition, diosgenin was found to reduce serum concentrations of proinflammatory cytokines and the activity of the hypothalamic-pituitary-adrenal (HPA) axis.
Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress
hypothalamic-pituitary-adrenal (HPA) axis.
https://pubmed.ncbi.nlm.nih.gov/36349650/
Diosgenin (Fig. 11.5) is a steroid saponin found in fenugreek seeds and yam [136]. Diosgenin has been found to be effective in ameliorating diabetic condition in both type 1 [137,138] and type 2 diabetes [139].
https://www.sciencedirect.com/topics/chemistry/diosgenin
We also know Fenugreek lowers SHBG and blood sugar. And now, knowing the possibility of FG possessing an antidepressant activity (a dosage of 20mg was used in the study) helps our ability to make an informed decision on what herbs to choose from.
The present study shows that diosgenin exerts the antidepressant activity, which is associated with the enhancement of neurotrophic function and the inhibition of inflammatory and neuroendocrine activities via the regulation of gut microbiota.
In addition, diosgenin was found to reduce serum concentrations of proinflammatory cytokines and the activity of the hypothalamic-pituitary-adrenal (HPA) axis.
Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress
hypothalamic-pituitary-adrenal (HPA) axis.
https://pubmed.ncbi.nlm.nih.gov/36349650/
Diosgenin (Fig. 11.5) is a steroid saponin found in fenugreek seeds and yam [136]. Diosgenin has been found to be effective in ameliorating diabetic condition in both type 1 [137,138] and type 2 diabetes [139].
https://www.sciencedirect.com/topics/chemistry/diosgenin
We also know Fenugreek lowers SHBG and blood sugar. And now, knowing the possibility of FG possessing an antidepressant activity (a dosage of 20mg was used in the study) helps our ability to make an informed decision on what herbs to choose from.
(26-01-2022, 09:12 AM)Lotus Wrote: Wild Yam has diosgenin, it blocks 16α-hydroxyestrone (16OH) which is the toxic form of estrogen and carcinogenic. Enhancing the production of 2-OH form is beneficial for breast health. Diosgenin stimulates growth of mammary epithelium, increase in DNA content and the number of ducts & terminal end buds
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