Here's my recent lab results. As mentioned in my previous post I was running an experiment (called micro-dosing) to raise my E2 percentage towards 2.0%. Normally I average 1.3% TO 1.5%.
As you can see my E2 (estradiol) is high (too high) @ 1370pg/mL. The experiment was administering .02 mg of estradiol valerate (localized to stomach areas in a pattern) every two days.
The experiment demonstrated (at least in part) that for the two days the dosing was too frequent for me…even using .02 mg of EV (estradiol valerate) which is a low dose.
A few takeaways are that even though my estradiol went through the roof it didn't do anything to raise that free E2%. It doesn't state on the lab report but the free E2% came back @ .137%...about what it was in October of last year, E2 was 460pg/mL at the time.
My lab results demonstrated that my high E2 became less effective at raising E2% as it increased. Instead my SHBG increased to 128 nmol/L. Oddly I didn't have any ill effects using the 2 day cycle. So now I'm on 3.5 days of E2 at .02 mg of subQ estradiol valerate. I'll probably do another lab test in a few months. I'm obviously sensitive to estradiol. As the saying goes "more isn't always better".
I do believe a similar thing happens using PM, meaning the more you use (2,500mg and over) of PM the less effective it becomes because you're raising SHBG which lowers free E2%...that's going in the wrong direction.
I'm including a post from some years ago about how we only have about 2% of free estradiol or free testosterone that's biologically active to interact with receptors. Total T or E2 isn't really biologically active…it's that 2% that can bind to receptors, make changes to DNA, proliferate cells, and cause growth.
![[Image: attachment.php?aid=19770]](https://www.breastnexum.com/attachment.php?aid=19770)
As you can see my E2 (estradiol) is high (too high) @ 1370pg/mL. The experiment was administering .02 mg of estradiol valerate (localized to stomach areas in a pattern) every two days.
The experiment demonstrated (at least in part) that for the two days the dosing was too frequent for me…even using .02 mg of EV (estradiol valerate) which is a low dose.
A few takeaways are that even though my estradiol went through the roof it didn't do anything to raise that free E2%. It doesn't state on the lab report but the free E2% came back @ .137%...about what it was in October of last year, E2 was 460pg/mL at the time.
My lab results demonstrated that my high E2 became less effective at raising E2% as it increased. Instead my SHBG increased to 128 nmol/L. Oddly I didn't have any ill effects using the 2 day cycle. So now I'm on 3.5 days of E2 at .02 mg of subQ estradiol valerate. I'll probably do another lab test in a few months. I'm obviously sensitive to estradiol. As the saying goes "more isn't always better".
I do believe a similar thing happens using PM, meaning the more you use (2,500mg and over) of PM the less effective it becomes because you're raising SHBG which lowers free E2%...that's going in the wrong direction.
I'm including a post from some years ago about how we only have about 2% of free estradiol or free testosterone that's biologically active to interact with receptors. Total T or E2 isn't really biologically active…it's that 2% that can bind to receptors, make changes to DNA, proliferate cells, and cause growth.
(23-03-2014, 10:08 PM)Lotus Wrote: What's Free Testosterone?
Free T is testosterone that is present within the bloodstream or not bound (locked) to a chemical called SHBG. But it's also the functional T, If we were to breakdown testosterone say like how we know estrogen is, i.e.. E1, E2, E3,
FT-(Free T) is about 2% the bioavailable part of testosterone that's
free to bind with androgen receptors. This is the same principle as to how free E2 is with estrogen receptors.
BT-Bound T or 98%
-which is 38% albumin (in the bloodstream)
-SHBG is 60% (sex-hormone-binding-globulin)
Leaving 2% free Testosterone….or 2% free E2 (estradiol)