First of all, there's bound to be similar threads. Tons of threads asking the same question, “Hey, has anyone tried this method… or, “I looked around here and didn't see the information I wanted, therefore it doesn't exist”. Which is ridiculous because 9 times out of 10 the information has been posted and discussed here. Ultimately, one has to put forth more effort into looking for it. Simply put, read till your eyes bleed. As TibetanPrincess would put it.
Secondly, why we experience testicular pain is simple, and it's called “ negative feedback”. The testes (and penis) have estrogen receptors, so, when testosterone is being instructed to produce less testosterone in genital tissue (testes & penis) via the hypothalamus axis/LH (Luteinizing Hormone) we experience the “negative feedback loop” from using phytoestrogens or estradiol… and using anti-androgens. Women experience negative feedback throughout their menstrual cycle, PCOS comes to mind. Even in hyperandrogenism we experience negative feedback… amongst other examples too.
Endocrinology of the Male Reproductive System and Spermatogenesis
CLINICAL SUMMARY
The testes synthesize two essential products: testosterone, needed for the development and maintenance of many physiological functions including normal testis function; and sperm, needed for male fertility. The synthesis of both products is regulated by endocrine hormones produced in the hypothalamus and pituitary, as well as locally within the testis.
What it means is that testosterone production of testosterone is turned down, that's when the hypothalamus recognizes the loss of testosterone production and produces more testosterone (which is termed supraphysiological reaction of said negative feedback). The feeling might last for 3-4 weeks once hemostasis is established (a return of receptor set points). You'll experience a reduction of penis/scrotum size because the testosterone/estrogen ratio is altered.
The secretion of hypothalamic gonadotropin-releasing hormone (GnRH) stimulates production of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the pituitary. LH is transported in the bloodstream to the testes, where it stimulates Leydig cells to produce testosterone: this can act as an androgen (via interaction with androgen receptors) but can also be aromatized to produce estrogens. The testes, in turn, feedback on the hypothalamus and the pituitary via testosterone and inhibin secretion, in a negative feedback loop to limit GnRH and gonadotropin production. Both androgens and FSH act on receptors within the supporting somatic cells, the Sertoli cells, to stimulate various functions needed for optimal sperm production. Spermatogenesis is the process by which immature male germ cells divide, undergo meiosis and differentiate into highly specialized haploid spermatozoa. Optimal spermatogenesis requires the action of both testosterone (via androgen receptors) and FSH.
https://www.ncbi.nlm.nih.gov/books/NBK279031/
I must've posted this information at least a dozen times over the 10+ years I've been at Breastnexum.
The science of negative feedback has been studied for years. I don't subscribe to the notion of "it's never been studied”… with all due respect, I find the information.
Secondly, why we experience testicular pain is simple, and it's called “ negative feedback”. The testes (and penis) have estrogen receptors, so, when testosterone is being instructed to produce less testosterone in genital tissue (testes & penis) via the hypothalamus axis/LH (Luteinizing Hormone) we experience the “negative feedback loop” from using phytoestrogens or estradiol… and using anti-androgens. Women experience negative feedback throughout their menstrual cycle, PCOS comes to mind. Even in hyperandrogenism we experience negative feedback… amongst other examples too.
Endocrinology of the Male Reproductive System and Spermatogenesis
CLINICAL SUMMARY
The testes synthesize two essential products: testosterone, needed for the development and maintenance of many physiological functions including normal testis function; and sperm, needed for male fertility. The synthesis of both products is regulated by endocrine hormones produced in the hypothalamus and pituitary, as well as locally within the testis.
What it means is that testosterone production of testosterone is turned down, that's when the hypothalamus recognizes the loss of testosterone production and produces more testosterone (which is termed supraphysiological reaction of said negative feedback). The feeling might last for 3-4 weeks once hemostasis is established (a return of receptor set points). You'll experience a reduction of penis/scrotum size because the testosterone/estrogen ratio is altered.
The secretion of hypothalamic gonadotropin-releasing hormone (GnRH) stimulates production of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the pituitary. LH is transported in the bloodstream to the testes, where it stimulates Leydig cells to produce testosterone: this can act as an androgen (via interaction with androgen receptors) but can also be aromatized to produce estrogens. The testes, in turn, feedback on the hypothalamus and the pituitary via testosterone and inhibin secretion, in a negative feedback loop to limit GnRH and gonadotropin production. Both androgens and FSH act on receptors within the supporting somatic cells, the Sertoli cells, to stimulate various functions needed for optimal sperm production. Spermatogenesis is the process by which immature male germ cells divide, undergo meiosis and differentiate into highly specialized haploid spermatozoa. Optimal spermatogenesis requires the action of both testosterone (via androgen receptors) and FSH.
https://www.ncbi.nlm.nih.gov/books/NBK279031/
I must've posted this information at least a dozen times over the 10+ years I've been at Breastnexum.
The science of negative feedback has been studied for years. I don't subscribe to the notion of "it's never been studied”… with all due respect, I find the information.