Oh I'd stay away from pioglitazone unless you taking it one month on and one month off for. No longer than 6-8 months and take a low dose if your going to..I think one a reddit page it said 30mgonce a day and no more than that. It also comes with rick of bladder cancer and you shouldn't take it if you've got heart problems or at risk of edema. It's quite a dangerous drug if you don't use it properly.... personally I'd stick with something herbal that isn't as strong or dangerous.