[Heaven's Night]

PM can cause DVT, oral estrogens can cause DVT, proper conventional HRT can not! Transdermal or injected BIOIDENTICAL estrogens do not elevate blood clotting factors much if at all. I had DVT symptoms from PM which scared the hell out of me, the aches went away when stopping and that was the last time I was on PM. Note that I was on PM quite successfully before HRT for quite some time, the problem only showed up later. Back then I also smoked quite heavily which did contribute to the problem, as I have naturally thick blood. Its a life saver, but with cigs and PM it could have turned out fatal.

But no, proper bioidentical E2 does not cause blood clots. The moment liver metabolism is out of question and the hormone itself isn't synthetic, this problem ceases to exist. Gel, patches and injections are super safe on this, approximately 95% bypasses the liver using these methods.