I found this interesting article about white matter relating to women who have had both of their ovaries removed and how they increase risk for white matter development in the brain of the long run. 


I found it interesting. I'm not sure if it really relates to your situation, but hopefully it may provide some insight/help if not also just be an interning read. 

https://www.sciencealert.com/losing-both-ovaries-could-come-at-a-serious-cost-to-the-brain-researchers-find