I'll answer this about what I know, DHEA and Prog both keep cancer risk low, E2 works topically when its balanced somehow and the topical protocol has every piece to keep the balance.

I started experiementing with topicals soon fourteen months ago, I added estradiol hemihydrate gel at one month mark. During that time I've grown aproximately four and half cupsizes and the pace has picked up considerably during last three months since latest additions to the program. The base of which has stayed exactly the same since starting out. I've even done estriol cream on the side, and topical DHEA does the E2 ---> E3 thing, think of that, that's several sources of local estrogens.

I don't think I've had this kind of development if receptors got fried, its a balance thing.