Hello!  I am not sure if this the correct thread to ask this, but I was recently using Bi-Est 2.5 (0.5 mcg estradiol and 2 mcg estriol) using scrotal application.  Normally I didn’t have any side effects however twice in about a month time frame I came down with what felt like terrible post nasal drip followed by insomnia and a mild cold for a couple of days, this was usually after I used one more pump than recommended at a time.  The first time I chalked up to coincidence but the twice in a little over a month.  Just wondering if anybody experienced anything similar with estradiol gels/creams, suggestions, recommendations moving forward, decided to take a break from it for now.  Thanks!