02-12-2012, 05:51 PM
I just found a research paper that talks about the Half-life of Miroestrol which I believe is the key phyto-estrogenic compund in PM. It stated that the Half-life of Miroestrol is 3.2 hours in women and 4.2 hours in men.
I played around with a spreadsheet a little ... looking at total blood levels when taking PM every 4 hours, 6, hours, 8 hours, and 12 hours. I used a value of "1" for each capsule (doesn't matter what the real number is since it ends up being proportionate) so after 4 hours (approx) that capsule would then have a value of ".5" in your system ... and after another 4 hours ".25" ... and so on ...
So then when you take the next capsule there is a residual PLUS another value of "1" for the new capsule .... and they are additive ... always adding whats already in your system from a previous capsule or capsules PLUS what is added from a new one.
When you total them and then graph them I thought it was pretty interesting .... as you lengthen the time between capsules two things happen .... the swing between the high lvel in your system and the low level in your system gets wider and wider ... plus any interval longer than 4 hours lower the maximum amount in your systems total ....
I would think you would want to minimize the swing and slowly work your way up to a level that produces the desired results ... I think you would end up taking less capsules each time BUT more frequently ...
Just something to think about
Karen .... and yup I'm still here
I played around with a spreadsheet a little ... looking at total blood levels when taking PM every 4 hours, 6, hours, 8 hours, and 12 hours. I used a value of "1" for each capsule (doesn't matter what the real number is since it ends up being proportionate) so after 4 hours (approx) that capsule would then have a value of ".5" in your system ... and after another 4 hours ".25" ... and so on ...
So then when you take the next capsule there is a residual PLUS another value of "1" for the new capsule .... and they are additive ... always adding whats already in your system from a previous capsule or capsules PLUS what is added from a new one.
When you total them and then graph them I thought it was pretty interesting .... as you lengthen the time between capsules two things happen .... the swing between the high lvel in your system and the low level in your system gets wider and wider ... plus any interval longer than 4 hours lower the maximum amount in your systems total ....
I would think you would want to minimize the swing and slowly work your way up to a level that produces the desired results ... I think you would end up taking less capsules each time BUT more frequently ...
Just something to think about
Karen .... and yup I'm still here