[AbiDrew85]

With respect to Steady-State vs. flucating daily rhytms of hormones. Estrogen levels during sleep are quite low when compared to peak concentrations which are typicall around 6-7am in the morning and then drop to its low level by mid-day and stay at the level. From the morning high to after average low, it's a 300-400% difference. There are flucuations through the day but as a mean of the top and bottom levels it peaks and then falls off. Maintaining a tight, steady-state concentration by dosing on the T1/2 is definitely altering the natural rhythm of a females cycle and even for NBE, I do not believe should be a suggested approach - especially for a female. As for a male, it's a relative new and poorly charter territory.

Wow. Seems I've been doing myself good and didn't even know it. I had no idea about the diurnal cycle. Only the monthly. But I've been dosing in full as soon as I wake up with my PM extract. My goals are to actually attempt to fully emulate a female cycle. It is my belief that this is the ideal for me personally, some of the reasons for that I'll go into below.

From the very very little bit of reading I have done male transformation, knocking out Test (by SP or other means) and dramatically increasing Estrogen will absolutely cause testicular shrinkage (due to lack of activity by the leydig cells i believe ie use it or lose it). With respect to Penis atrophy, the lack of nocturnal erections and lack of sex drive experienced by many when transitioning to predominately female based hormones (irregardless of they are synthetic Estrogen's or phytoestrogens). However, probably not an issue either way but I do not even begin to understand or appreciate the pyschological impact that such an individual is going through. As a man ages after 40-50, the penis does atrophy due to the lose of nocturnal erections due lower hormone levels (GH and Test).. slowly but it does. I recall reading somewhere that it can be by as much as 1/2 or more loss in length and rigidity. But that data was pre-Viagara type products. I guess men transitioning to women do also see the changes unless they are not on female hormone replacement therapy or still masturbate or have sex frequently. I guess even within that community, there are different levels of transgenders feminization...

That research is actually kind of divisive. There's segments of the transgender community who perhaps aren't QUITE as "female" as others who yes, they lose sex drive and all sexual functionality on HRT. Then there's those that it kinda just lessens a little, but it's still there. And then there's the ones who respond like me, and when they're given even just a little bit of E and their T is being fully suppressed their sex drive goes through the roof - just like, I might point out, a genetic woman.

It is my belief that the lattermost group of which I am a part of would and do benefit most from simulating a regular female cycle as closely as possible.

The other groups? I doubt it matters too much either way. Though I suspect they'll get better physical transformations through emulating the female cycle. After all, we all too often see women with no or very irregular periods who're underdeveloped. We also tend to see a high proportion of underdeveloped T-girls. I do not believe that correlation to be a coincidence.