28-02-2013, 10:10 PM
(This post was last modified: 28-02-2013, 10:11 PM by chrishoney.)
Seems like the evidence and interpretation of it is controversial. LH stimulation in intact males can be affected at the pituitary or the hypothalmus. If you want to exercise your higher reasoning faculties, check out this study:
http://jcem.endojournals.org/content/93/3/784.full
Then add to that the conclusion of this study showing LH increases E2 production by it's effect on the gene regulating aromatase activity:
http://www.biolreprod.org/content/68/5/1562.full
Then there's this study examining the direct inhibitory effects of E2 on T production with concomitant effects on LH and FSH.
http://www.ncbi.nlm.nih.gov/pubmed/1908485/
And just to be sure you fully understand the negative feedback mechanism of testosterone (apparently it has an indirect, negative effect through the process of being aromatized to E2), there's this study:
http://www.ncbi.nlm.nih.gov/pubmed/1908484
And SHAZAM! My brain hurts and I'm still confused. Your NP could be right, though it sounds more likely to be a bit more complicated than that, especially if you are taking PM which would not show up on ANY of the tests for serum hormone levels. It might go something like this (then again, it might not, this is just my guess): PM mimics E2 and inhibits T production, low T increases LH production which then stimulates aromatase activity, lowering T levels even more. However, high E2 levels also inhibit LH production, so the question remains, does PM also inhibit LH?
Oh bother.
What is it exactly that you need help with here, anyway?
http://jcem.endojournals.org/content/93/3/784.full
Then add to that the conclusion of this study showing LH increases E2 production by it's effect on the gene regulating aromatase activity:
http://www.biolreprod.org/content/68/5/1562.full
Then there's this study examining the direct inhibitory effects of E2 on T production with concomitant effects on LH and FSH.
http://www.ncbi.nlm.nih.gov/pubmed/1908485/
And just to be sure you fully understand the negative feedback mechanism of testosterone (apparently it has an indirect, negative effect through the process of being aromatized to E2), there's this study:
http://www.ncbi.nlm.nih.gov/pubmed/1908484
And SHAZAM! My brain hurts and I'm still confused. Your NP could be right, though it sounds more likely to be a bit more complicated than that, especially if you are taking PM which would not show up on ANY of the tests for serum hormone levels. It might go something like this (then again, it might not, this is just my guess): PM mimics E2 and inhibits T production, low T increases LH production which then stimulates aromatase activity, lowering T levels even more. However, high E2 levels also inhibit LH production, so the question remains, does PM also inhibit LH?
Oh bother.
What is it exactly that you need help with here, anyway?

