11-03-2013, 12:10 PM
In my opinion, you're missing a few important points. Sublingual administration does NOT avoid metabolism by the liver. It only avoids the dreaded "first pass" through the hepatic portal vein system. I have posted on this misconception before.
Also, the liver most certainly DOES have the enzymes to clear the key ingredients of PM from the system, or all of us using it would gradually accumulate so much that we would find an LD-50 the hard way (which in case you are wondering, has not been determined using the usual animal models.) The "first pass" phobia that most MtF transexual women have is from a bygone era when weak and dangerous forms of estrogen HRT were all that was available to help them transition. Avoiding the first pass with PM may actually decrease it's effectiveness as Pansy-Mae pointed out.
For me, buying bulk PM and a US$10 capsule filler is WAY easier and cheaper than messing around with creating tinctures, but to each his own.
Also, the liver most certainly DOES have the enzymes to clear the key ingredients of PM from the system, or all of us using it would gradually accumulate so much that we would find an LD-50 the hard way (which in case you are wondering, has not been determined using the usual animal models.) The "first pass" phobia that most MtF transexual women have is from a bygone era when weak and dangerous forms of estrogen HRT were all that was available to help them transition. Avoiding the first pass with PM may actually decrease it's effectiveness as Pansy-Mae pointed out.
For me, buying bulk PM and a US$10 capsule filler is WAY easier and cheaper than messing around with creating tinctures, but to each his own.