[AnnieBL]

At the risk of being repetitious, there is a distinction to be made between personal and public risk. Most highly publicised pharma rrisks are public health risks where eve a small incidence of adverse side effects can be a big problem. At a personal level, these low incidences may constitute an acceptable risk, particularly when one is driven by strong compulsions.

You mention that PM sparks a powerful insulin response. Can you enlarge on this? I'm not diabetic, nor even near, but big insulin spikes are undesirable for all of us.