[flamesabers]

How the heck would you decide on the right amount of PG anyway? Rub some on until you feel better? What about the placebo effect?

Like I say, unless an orchiectomy is involved, it's going to make very little difference how much progesterone is used, the mix of hormones is still going to be "wrong." How would anyone work out the perfect balance of estrogen, progesterone, and testosterone for an MTF TS/TG? For one thing, the estrogen/progesterone balance varies in GGs with a monthly cycle which we don't have, but even trying to simulate it (hard without a blood lab), what about the HUGE imbalance of testosterone?

It would be convenient to have all the answers on this subject. As you mentioned though, it's a bit of guesswork until scientists develop a comprehensive explanation.

My thoughts on this issue is finding the right amount of PG to balance estrogen is more of a spectrum than either or. I suspect the body tries to compensate and reach an equilibrium, no matter whether the person is taking pm and using PG.