[MonikaT]

The differences you and Misty note may be why others, like me, are having issues even with lower doses. Mine have been largely gastrointestinal, and might be related to the prescription medication metformin, but I have had problems. I started with 500 mg/day on Feb 19, and I finally made it to 1500 mg about a week ago, but I have had to jump through some hoops to get here. I take 2 mg of loperamide at bed time (it is known as Imodium and is available over the counter in the US). I also have to take a healthy dose of psyllium before meals, then take my medications and other supplements, including PM, after the meal or else the results are explosive. The psyllium helps to regulate everything, especially if I consume too much dietary fat, such as the amount of butter or margarine one might reasonably use on a couple pieces of toast. I've also had to almost completely eliminate coffee as it speeds up everything too much.

R1 is the only form of PM I've ever tried. I guess the good news is if 1000 mg does for you what used to require 2 or 3 times as much, it will be cheaper in the long run.