Hey all. Long time lurker pulled out from under the rock. Xxd almost pulled me out with his scientific approach to NBE.
This has been a question I have thought of often. (No, nothing about the off topic thread stealing conversation of anti freeze).
Rectal medication administration, in my opinion would be a more concentrated systemic delivery mechanism. Yes, all blood will pass through the liver. The first pass metabolism of the stomach will break down some of the drug. If you are taking the drugs on any empty stomach, it will pass through faster, leading to less destruction of the drug.
My question is where this drug is most optimally absorbed. Some are better absorbed by the intestine, others through stomach wall lining. You will notice that many drugs are coated. This is to provide a buffer to the stomach acid break down (denaturing) of the active chemicals.
Upper intestinal absorption, just like the stomach, goes to the liver. Stomach absorption hits the same blood stream as the intestine and goes to the liver first.
However, the lower (and mid) intestine will bypass the liver for the first pass. I don't know about the actually conversion of the chemicals (others on the site apparently do), and whether the liver is in deed needed or not. If it is not needed (contrary to what was said in this post alone) then the lower administration would be better. If it needs to be broken down by the liver, then the drug will be in the blood stream a bit longer, being less effective. However, there will be more drug in the stream as it was broken down less.
However, there is the mechanism of absorption in the lower intestine. Is the drug too large? Is it too polar (molecular charge)? Powder would be quite poor compared to a liquid suspension. Is it acidic (alkaline is better absorbed)?
And then you need to be worried about intestinal wall irritation and even damage if the chemicals are too harsh.
Hmm, I guess those university bio-psychology courses did actually sink in somewhere.
Hope this helps.
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Editted: Further clarification
This has been a question I have thought of often. (No, nothing about the off topic thread stealing conversation of anti freeze).
Rectal medication administration, in my opinion would be a more concentrated systemic delivery mechanism. Yes, all blood will pass through the liver. The first pass metabolism of the stomach will break down some of the drug. If you are taking the drugs on any empty stomach, it will pass through faster, leading to less destruction of the drug.
My question is where this drug is most optimally absorbed. Some are better absorbed by the intestine, others through stomach wall lining. You will notice that many drugs are coated. This is to provide a buffer to the stomach acid break down (denaturing) of the active chemicals.
Upper intestinal absorption, just like the stomach, goes to the liver. Stomach absorption hits the same blood stream as the intestine and goes to the liver first.
However, the lower (and mid) intestine will bypass the liver for the first pass. I don't know about the actually conversion of the chemicals (others on the site apparently do), and whether the liver is in deed needed or not. If it is not needed (contrary to what was said in this post alone) then the lower administration would be better. If it needs to be broken down by the liver, then the drug will be in the blood stream a bit longer, being less effective. However, there will be more drug in the stream as it was broken down less.
However, there is the mechanism of absorption in the lower intestine. Is the drug too large? Is it too polar (molecular charge)? Powder would be quite poor compared to a liquid suspension. Is it acidic (alkaline is better absorbed)?
And then you need to be worried about intestinal wall irritation and even damage if the chemicals are too harsh.
Hmm, I guess those university bio-psychology courses did actually sink in somewhere.
Hope this helps.
----
Editted: Further clarification