16-12-2013, 01:34 AM
Thank you very much for your reply. I'm sorry to have been so long getting back to this, but I've had other things on my mind.
While SP is generally supposed to act as a 5AR inhibitor, and has been shown to do so in vitro, it is not clear what component of this complex herb is responsible, and its effectiveness in vivo as a 5AR inhibitor has been questioned, it being theorized that its effectiveness in protecying the prostate from DHT depends more on its preventing DHT from binding to receptors in the prostate than from preventing conversion of T to DHT. This could explain why it does not like Proscar lower PSA scores nor reduce overall DHT levels. If this is correct, then it would also not effect DHT levels in women. It is alleged to improve the response to estrogen in some manner (how?).. Some say that the effective constituent in SP is beta-sitosterol, but there is only a small amount of it in SP, much less than found in many other foods and supplements. Those that say that beta-sitosterol is three hundred times more powerful than SP are merely saying that a typical dose of BS contains 300 time as much BS as does SP. There is also the question of whether SP has any effect on the sphincter connecting the bladder to the urethra since impaired function of this sphincter can produce symptoms similar to those due to an enlarged prostate constricting the portion of the urethra within the prostate. Such impaired function may be caused by bladder stones or spasm of the detrusor muscle lining the bladder caused by other factors. In actual fact I have begun to suspect that SP actually reduces the effectiveness of the oxybutynin I am taking for overactive bladder so I am stopping taking it for now, particularly since I get a significant amount of BS in other ways.
For better or worse (i begin to think better) my testicles and penis are already severely atrophied to a degree such that I can't believe that SP could make any noticeable change in my long non-existent male function. My real interest was in whether in such circumstances it had any place as an adjunct to phytoestrogens in in my NBE program.
While SP is generally supposed to act as a 5AR inhibitor, and has been shown to do so in vitro, it is not clear what component of this complex herb is responsible, and its effectiveness in vivo as a 5AR inhibitor has been questioned, it being theorized that its effectiveness in protecying the prostate from DHT depends more on its preventing DHT from binding to receptors in the prostate than from preventing conversion of T to DHT. This could explain why it does not like Proscar lower PSA scores nor reduce overall DHT levels. If this is correct, then it would also not effect DHT levels in women. It is alleged to improve the response to estrogen in some manner (how?).. Some say that the effective constituent in SP is beta-sitosterol, but there is only a small amount of it in SP, much less than found in many other foods and supplements. Those that say that beta-sitosterol is three hundred times more powerful than SP are merely saying that a typical dose of BS contains 300 time as much BS as does SP. There is also the question of whether SP has any effect on the sphincter connecting the bladder to the urethra since impaired function of this sphincter can produce symptoms similar to those due to an enlarged prostate constricting the portion of the urethra within the prostate. Such impaired function may be caused by bladder stones or spasm of the detrusor muscle lining the bladder caused by other factors. In actual fact I have begun to suspect that SP actually reduces the effectiveness of the oxybutynin I am taking for overactive bladder so I am stopping taking it for now, particularly since I get a significant amount of BS in other ways.
For better or worse (i begin to think better) my testicles and penis are already severely atrophied to a degree such that I can't believe that SP could make any noticeable change in my long non-existent male function. My real interest was in whether in such circumstances it had any place as an adjunct to phytoestrogens in in my NBE program.