(06-11-2014, 11:35 PM)ELLACRAIG Wrote: I suspected this was coming. Well done u lucky sod
Yup!, I figured I should post one like that before I say goodbye. Now, I'm not into doing a farewell tour, lol. I told myself when it's my time to go I'll just stop posting, then I thought that would suck, how many times has that happened already and we are left scratching our heads wondering why, (but we all have our reasons). I guess imo I'm just full of shit lol, course maybe that's true of all of us in one way or another. With the exception of the DHEA experiment I haven't done NBE (cept maybe WP) in a long time, (no to HRT).
I could say I'm goin fishin, write a book, ha!, read a book, (that'll be the day!), spend more time with family, (which would be totally right). Not that I don't love all you crazy people (which I do, or don't j/k). Honestly, I do have a huge migraine lol from all the stuff I've found and uncovered about NBE. I'm not gonna say "oh, I've posted x-many posts and threads to my credit", ok maybe I will......nah!, had ya goin!
I will this say though!, I'm better at being a dude than trying to be a gurl. If life were different and I had a choice, it's a no brainer. Imo, even if the scale tipped a little more female I wouldn't put my family through my transition, that's just me though. Thanks to Eve, Breast Nexus is by all accounts gender non-descript, that's what makes this place so flippin awesome.
So, good-bye for now dear friends, you won't know how to reach me cause I lost my Email, (no really I did).
Oh, just remember!, it's just boobs people.
Lotus, signing off! (too cheesy?), when I need a laugh, all I have to do is remember the special moments here. Never say never right?, who knows maybe I'll come back to haunt you!.
Love ya!
(07-11-2014, 01:45 AM)Lotus Wrote:(06-11-2014, 11:35 PM)ELLACRAIG Wrote: I suspected this was coming. Well done u lucky sod
Yup!, I figured I should post one like that before I say goodbye. Now, I'm not into doing a farewell tour, lol. I told myself when it's my time to go I'll just stop posting, then I thought that would suck, how many times has that happened already and we are left scratching our heads wondering why, (but we all have our reasons). I guess imo I'm just full of shit lol, course maybe that's true of all of us in one way or another. With the exception of the DHEA experiment I haven't done NBE (cept maybe WP) in a long time, (no to HRT).
I could say I'm goin fishin, write a book, ha!, read a book, (that'll be the day!), spend more time with family, (which would be totally right). Not that I don't love all you crazy people (which I do, or don't j/k). Honestly, I do have a huge migraine lol from all the stuff I've found and uncovered about NBE. I'm not gonna say "oh, I've posted x-many posts and threads to my credit", ok maybe I will......nah!, had ya goin!
I will this say though!, I'm better at being a dude than trying to be a gurl. If life were different and I had a choice, it's a no brainer. Imo, even if the scale tipped a little more female I wouldn't put my family through my transition, that's just me though. Thanks to Eve, Breast Nexus is by all accounts gender non-descript, that's what makes this place so flippin awesome.
So, good-bye for now dear friends, you won't know how to reach me cause I lost my Email, (no really I did).
Oh, just remember!, it's just boobs people.
Lotus, signing off! (too cheesy?), when I need a laugh, all I have to do is remember the special moments here. Never say never right?, who knows maybe I'll come back to haunt you!.
Love ya!
Omg ! Nooooooo ! Everyone I got to know over the long yrs I been here are abandoning ! Especially lotus who many plebs like have looked upto as a shining star as person who would help any idiot like me . The understanding of Nbe and knowledge parted here is beyond words . WHY leave ? Could always cut down visits ! I an devastated
(07-11-2014, 02:30 AM)myboobs Wrote:(07-11-2014, 01:45 AM)Lotus Wrote:(06-11-2014, 11:35 PM)ELLACRAIG Wrote: I suspected this was coming. Well done u lucky sod
Yup!, I figured I should post one like that before I say goodbye. Now, I'm not into doing a farewell tour, lol. I told myself when it's my time to go I'll just stop posting, then I thought that would suck, how many times has that happened already and we are left scratching our heads wondering why, (but we all have our reasons). I guess imo I'm just full of shit lol, course maybe that's true of all of us in one way or another. With the exception of the DHEA experiment I haven't done NBE (cept maybe WP) in a long time, (no to HRT).
I could say I'm goin fishin, write a book, ha!, read a book, (that'll be the day!), spend more time with family, (which would be totally right). Not that I don't love all you crazy people (which I do, or don't j/k). Honestly, I do have a huge migraine lol from all the stuff I've found and uncovered about NBE. I'm not gonna say "oh, I've posted x-many posts and threads to my credit", ok maybe I will......nah!, had ya goin!
I will this say though!, I'm better at being a dude than trying to be a gurl. If life were different and I had a choice, it's a no brainer. Imo, even if the scale tipped a little more female I wouldn't put my family through my transition, that's just me though. Thanks to Eve, Breast Nexus is by all accounts gender non-descript, that's what makes this place so flippin awesome.
So, good-bye for now dear friends, you won't know how to reach me cause I lost my Email, (no really I did).
Oh, just remember!, it's just boobs people.
Lotus, signing off! (too cheesy?), when I need a laugh, all I have to do is remember the special moments here. Never say never right?, who knows maybe I'll come back to haunt you!.
Love ya!
Omg ! Nooooooo ! Everyone I got to know over the long yrs I been here are abandoning ! Especially lotus who many plebs like have looked upto as a shining star as person who would help any idiot like me . The understanding of Nbe and knowledge parted here is beyond words . WHY leave ? Could always cut down visits ! I an devastated
Agreed. What's this place without out fearless leader.
If you indeed are signing off for good, Lotus, fare the well. You have been a font of information and good spirit. I for one will miss you mightily.
I took Black Cohosh for around 6 months. I could feel that I no longer had normal T levels, I basically felt like a wet dish rag and could sleep all day every day. Went to the Doctors for an unrelated thing, he took blood tests and because I had said I was curious how my hormone levels were he also ordered those. He called me at home and asked me to come in. When I did he looked at me and said, "well, your testosterone levels are in the basement, almost non existent".
I had been on a good breast growth spurt at that time. But the doc ordered me off the black cohosh and wanted to check me again in six weeks. Since I made that change and stopped the black cohosh (kept taking pm though) my breast growth slowed and seems to have halted. I had got up to a B cup too.
Started the Black Cohosh once again just this morning, hoping it will inspire new growth, along with the pm
I had been on a good breast growth spurt at that time. But the doc ordered me off the black cohosh and wanted to check me again in six weeks. Since I made that change and stopped the black cohosh (kept taking pm though) my breast growth slowed and seems to have halted. I had got up to a B cup too.
Started the Black Cohosh once again just this morning, hoping it will inspire new growth, along with the pm
(07-11-2014, 04:30 PM)ooBobbi Wrote: I took Black Cohosh for around 6 months. I could feel that I no longer had normal T levels, I basically felt like a wet dish rag and could sleep all day every day. Went to the Doctors for an unrelated thing, he took blood tests and because I had said I was curious how my hormone levels were he also ordered those. He called me at home and asked me to come in. When I did he looked at me and said, "well, your testosterone levels are in the basement, almost non existent".
I had been on a good breast growth spurt at that time. But the doc ordered me off the black cohosh and wanted to check me again in six weeks. Since I made that change and stopped the black cohosh (kept taking pm though) my breast growth slowed and seems to have halted. I had got up to a B cup too.
Started the Black Cohosh once again just this morning, hoping it will inspire new growth, along with the pm
Just the BC with the PM, or anything else ??
Mainly the PM is regular. I try to keep the PM flowing regularly without interruption. Off and on i will take fenugreek which really builds up the glands in the breasts. I am pretty certain it was fenugreek which connected my breasts to the rest of my body. I had never had sensations all through my whole body before, and now? Well now playing with my breasts can bring on orgasm by itself.
Off and on I also take saw palmetto, however the research on that is still contradictory. Female sites tend to say that it is good to lower testosterone levels, while other male sites say that it is good to raise T levels. My hair grows faster, thicker and stronger while on saw, so, I am not certain of that one still.
Off and on I also take the black cohosh. I take this less though because it really is an effective antiandrogen, big time, and you feel it. For me, it wipes me out really bad so i can't stay on that one for too long without breaks.
Breast grow has stalled though, and maybe even stopped. I have to do something to inspire new growth.
Off and on I also take saw palmetto, however the research on that is still contradictory. Female sites tend to say that it is good to lower testosterone levels, while other male sites say that it is good to raise T levels. My hair grows faster, thicker and stronger while on saw, so, I am not certain of that one still.
Off and on I also take the black cohosh. I take this less though because it really is an effective antiandrogen, big time, and you feel it. For me, it wipes me out really bad so i can't stay on that one for too long without breaks.
Breast grow has stalled though, and maybe even stopped. I have to do something to inspire new growth.
(07-11-2014, 04:52 PM)ooBobbi Wrote: Mainly the PM is regular. I try to keep the PM flowing regularly without interruption. Off and on i will take fenugreek which really builds up the glands in the breasts. I am pretty certain it was fenugreek which connected my breasts to the rest of my body. I had never had sensations all through my whole body before, and now? Well now playing with my breasts can bring on orgasm by itself.
Off and on I also take saw palmetto, however the research on that is still contradictory. Female sites tend to say that it is good to lower testosterone levels, while other male sites say that it is good to raise T levels. My hair grows faster, thicker and stronger while on saw, so, I am not certain of that one still.
Off and on I also take the black cohosh. I take this less though because it really is an effective antiandrogen, big time, and you feel it. For me, it wipes me out really bad so i can't stay on that one for too long without breaks.
Breast grow has stalled though, and maybe even stopped. I have to do something to inspire new growth.
From Lotus`s thread :
"Black Cohosh-The weak estrogen like effects of black cohosh suppressed increased luteinizing hormone secretion in menopausal women, and this effect was specifically linked with a reduction in the incidence of hot flashes (Duker et al. 1991). Black cohosh extract has shown estrogenic effects within the body in several studies, but it does not elevate estrogen levels in the blood. Black cohosh extract appears to bind to estrogen receptors in order to mimic the hormonal effects of the weak estrogen, estriol."
I had originally stayed away from BC because of its weak estrogen like effects ( i did not want it to compete with my PM ) but, If I read into it a little more : In men, LH is also produced in the pituitary gland. LH binds to receptors in certain cells in the testes called Leydig cells. This leads to the release of testosterone, a hormone that is necessary for producing sperm cells. So I would think the BC is shutting the tests down, by suppressing the LH.
Maybe worth while cycling it in and out.
This post was last modified: 07-11-2014, 10:42 PM by undecided.
Exp Mol Pathol. 2014 Jun;96(3):279-83.
Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liver biopsies with clinical correlation.
Enbom ET, Le MD, Oesterich L, Rutgers J, French SW.
Abstract
BACKGROUND: Consumption of herbal supplements in the developed world remains high. Cimicifuga racemosa (C. racemosa) extract, or black cohosh, is widely used as a hormone replacing and an anti-inflammatory agent, and has been shown to cause idiosyncratic hepatitis. The mechanism of acute liver injury in those cases is unclear. To date, hepatotoxic effects of C. racemosa have been studied mostly in vitro and in animal models. Data on human tissue is extremely limited, and mostly confined to histological findings of explanted livers. METHODS: We evaluated clinical data and examined surgical diagnostic liver biopsy specimens obtained from two female patients, who developed acute submassive liver necrosis, following consumption of C. racemosa. Both patients presented with acute elevation of liver enzymes, cholestasis, absence of reactivity to hepatitis A, B and C antibodies, and weak non-specific positivity for autoimmune serological markers. Initial histological interpretation of the biopsies, with focus on hepatic parenchyma and portal tracts, was done by light microscopy, followed by special stain series and immunohistochemical studies, including Cam 5.2, AE1/AE3, reticulin, α-actin, sirius red, and PAS with diastase. Areas of prominent lymphocytic infiltration of the periportal liver plate, observed microscopically, were further evaluated by electron microscopy (EM). 4HNE adduction study, an immunofluorescent assay, was performed to detect products of the oxidative damage and their localization in the liver parenchyma. RESULTS: Oxidative damage was evident by accumulation of 4HNE protein adducts in the cytoplasm of hepatocytes, secondary lysosomes and macrophages. We hypothesize that the adducted proteins, accumulated in the liver parenchyma, serve as autoantigens, which provoke an autoimmune response, and cause migration of lymphocytes to the affected regions. The formation of immunological synapses between hepatocytes and lymphocytes, predominantly T-lymphocytes, is demonstrated by electron microscopy. The autoimmune response induces piecemeal, or troxis necrosis of hepatocytes, a well described biological phenomenon, where lymphocytes gradually remove hepatocytes in a piecemeal fashion, slowly consuming them and leaving fragments of liver cells, or nubbins of anuclear cytoplasm of liver cell, at the interface between lymphocytes and hepatocytes. CONCLUSION: The pattern of pathological injury of liver cells in both patients, following consumption of black cohosh, is identical to troxis necrosis, seen during autoimmune hepatitis. Recognition of the possibility of the acute hepatic injury by the herbal supplement black cohosh is essential for early accurate diagnosis, and timely patient management.
PMID: 24657312
Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liver biopsies with clinical correlation.
Enbom ET, Le MD, Oesterich L, Rutgers J, French SW.
Abstract
BACKGROUND: Consumption of herbal supplements in the developed world remains high. Cimicifuga racemosa (C. racemosa) extract, or black cohosh, is widely used as a hormone replacing and an anti-inflammatory agent, and has been shown to cause idiosyncratic hepatitis. The mechanism of acute liver injury in those cases is unclear. To date, hepatotoxic effects of C. racemosa have been studied mostly in vitro and in animal models. Data on human tissue is extremely limited, and mostly confined to histological findings of explanted livers. METHODS: We evaluated clinical data and examined surgical diagnostic liver biopsy specimens obtained from two female patients, who developed acute submassive liver necrosis, following consumption of C. racemosa. Both patients presented with acute elevation of liver enzymes, cholestasis, absence of reactivity to hepatitis A, B and C antibodies, and weak non-specific positivity for autoimmune serological markers. Initial histological interpretation of the biopsies, with focus on hepatic parenchyma and portal tracts, was done by light microscopy, followed by special stain series and immunohistochemical studies, including Cam 5.2, AE1/AE3, reticulin, α-actin, sirius red, and PAS with diastase. Areas of prominent lymphocytic infiltration of the periportal liver plate, observed microscopically, were further evaluated by electron microscopy (EM). 4HNE adduction study, an immunofluorescent assay, was performed to detect products of the oxidative damage and their localization in the liver parenchyma. RESULTS: Oxidative damage was evident by accumulation of 4HNE protein adducts in the cytoplasm of hepatocytes, secondary lysosomes and macrophages. We hypothesize that the adducted proteins, accumulated in the liver parenchyma, serve as autoantigens, which provoke an autoimmune response, and cause migration of lymphocytes to the affected regions. The formation of immunological synapses between hepatocytes and lymphocytes, predominantly T-lymphocytes, is demonstrated by electron microscopy. The autoimmune response induces piecemeal, or troxis necrosis of hepatocytes, a well described biological phenomenon, where lymphocytes gradually remove hepatocytes in a piecemeal fashion, slowly consuming them and leaving fragments of liver cells, or nubbins of anuclear cytoplasm of liver cell, at the interface between lymphocytes and hepatocytes. CONCLUSION: The pattern of pathological injury of liver cells in both patients, following consumption of black cohosh, is identical to troxis necrosis, seen during autoimmune hepatitis. Recognition of the possibility of the acute hepatic injury by the herbal supplement black cohosh is essential for early accurate diagnosis, and timely patient management.
PMID: 24657312
I just learned about Lotus leaving us, and it made me sad. I am not getting any notifications on my subscribed threads since Halloween!!! I checked the threads and they all say that I am set for immediate notifications. This even has happened to my own threads. Ella has posted couple posts om my thread "POM's Progress" on 11-2-14 and I did not get them until I was checking my threads and saw them on 11-4-14. Sorry Ella for responding so late. So strange. POM
(advertisement)