It's all to do with shinkage; you can be left with too little tissue, to create the vagina.

PM contains β-sitosterol, which is an anti-androgen.

PM contains β-sitosterol, which is an anti-androgen.

How effective is it compared to SP or finasteride? Does anyone know? It would be nice to make my pharmacy smaller.

Beverley

On the other hand β-sitosterol inhibited 5α -reductase
activity with a value of IC50 2.7 µM, as compared to
that of finasteride of 10.12 nM.
http://www.medicine.nevada.edu/wps/Proceedings/46/153-155-Vol46P153T155.pdf
So you have to take 270 times more β-sitosterol. How much finasteride do you need?

So you have to take 270 times more β-sitosterol. How much finasteride do you need?

I have no idea.

The next question is how much β-sitosterol do you get from 1 x 500mg dose of PM?

Beverley

I'm afraid nobody ever measured that. My guess is: enough. Women who take 500 mg already see their acne clearing up. You have to add it up to what you get from other plants too, like even maize. The list starts bottom right on p. 27:
http://www.dweckdata.com/Published_papers/IJCD.pdf

beverley.rose, chrissie , Pansy-Mae, Isabelle: Thanks all for your reply. I am still thinking about to start, not sure, i am afraid about side effects, and the impact around me, i wonder if the effects of getting breasts, etc are permanent, or if i left taking PM i will back to my actual state? i am a 34 years old man.

thanks and regards.

I am still thinking about to start, not sure, i am afraid about side effects, and the impact around me, i wonder if the effects of getting breasts, etc are permanent, or if i left taking PM i will back to my actual state?

For the first couple of months it is reversible. i.e, until proper noticeable breast tissue formation ("budding"). Anything that develops up to that point is simply fat redistribution and it will go back to male pattern if you stop PM.
However actual breast tissue is permanent, although, again, the fat associated with it, isn't.

So you could try PM for a while to see how you get on with it, but IMO you shouldn't go that route if you are having doubts before you even start.

I am still thinking about to start, not sure, i am afraid about side effects, and the impact around me, i wonder if the effects of getting breasts

I agree with Pansy-Mae. You have doubts so do not do this.

Beverley

I'm afraid nobody ever measured that. My guess is: enough. Women who take 500 mg already see their acne clearing up. You have to add it up to what you get from other plants too, like even maize. The list starts bottom right on p. 27:
http://www.dweckdata.com/Published_papers/IJCD.pdf

You might like this http://www.puerariathai.com/pueraria-mirifica/clinical-information.htm

OTHER INGREDIENT CRITERIA & HUMIDITY
Analysis Result (s) Method
Miroestrol 76.00 ppm HPLC
Puerarin 40.00 ppm HPLC
Daidzin 0.56 mg/100gm. HPLC
Daidzein Less Than 10% HPLC
Genistin Less Than 10% HPLC

Beverley